HCID 59295493, compound → HCID 59295485, compound

HRID 2233297Notes

Reaction equation

HRID 2233297 reaction equation
[F:1][C:2]([F:23])([CH:21]=[CH2:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:11]=[N:12][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:15]=2)=[N:7][C:6]=1[CH3:20])[OH:4]>C(OCC)(=O)C.[Pd]>[F:23][C:2]([F:1])([CH2:21][CH3:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:11]=[N:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=2)=[N:7][C:6]=1[CH3:20])[OH:4]

Participants

4

Reactant 1

HCID 59295493HCID 59295493, compound

Product 1

HCID 59295485HCID 59295485, compoundYield 97.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

500 mg 2,2-Difluoro-1-[4-methyl-2-(6-trifluoromethyl-pyridin-3-yl)-thiazol-5-yl]-but-3-en-1-ol were dissolved in 50 ml ethyl acetate. 50 mg palladium (5% on charcoal) were added and the reaction mixture stirred at room temperature under a hydrogen atmosphere. After three hours the catalyst was filtered off and the filtrate evaporated in vacuo to obtain 490 mg 2,2-Difluoro-1-[4-methyl-2-(6-trifluoromethyl-pyridin-3-yl)-thiazol-5-yl]-butan-1-ol as a white solid.

Workup

  1. filtrationAfter three hours the catalyst was filtered off
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-7ca0b50e90944b3fb17928026517bf9b
Source dataset
uspto-grants-2010_05
Patent number
US07709481B2

Reaction notes

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