反应详情

7.8 g (0.039 mol) of 4-chloro-5-fluoroisatin are suspended in 50 ml of 100 percent acetic acid, treated with 0.25 ml of concentrated sulphuric acid and then at 30° 4.4 ml (0.043 mol) of 30 percent hydrogen peroxide are added thereto. The mixture is subsequently heated to 70° for 2.5 hours, then cooled to 10° and filtered. The crude product is recrystallized from acetone/hexane, there being obtained 6-chloro-5-fluoroisatoic acid anhydride of melting point 275°-278° (decomposition).

1. temperatureThe mixture is subsequently heated to 70° for 2.5 hours
2. temperaturecooled to 10°
3. filtrationfiltered
4. customThe crude product is recrystallized from acetone/hexane, there