HCID 68580143, compound → HCID 23658347, compound

HRID 2233324Notes

Reaction equation

HRID 2233324 reaction equation
[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:11][N:10]=[C:9]([S:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]3[CH2:27][CH:26]3[C:28]([O:30]C(C)(C)C)=[O:29])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>ClCCl.C(O)(C(F)(F)F)=O>[C:1]1([C:7]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:11][N:10]=[C:9]([S:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]3[CH2:27][CH:26]3[C:28]([OH:30])=[O:29])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 68580143HCID 68580143, compound

Product 1

HCID 23658347HCID 23658347, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

96 mg (0.2 mmol) of tert-butyl 2-[5-(4,5-diphenylpyrimidin-2-ylsulfanyl)pentyl]-cyclopropanecarboxylate were dissolved in a mixture of 2 ml of dichloromethane and 2 ml of TFA and stirred at room temperature for 2 hours. The residue after removal of all volatile constituents in vacuo was purified by preparative HPLC (method A). 60 mg (87%) of the desired product were obtained.

Workup

  1. customThe residue after removal of all volatile constituents in vacuo
  2. customwas purified by preparative HPLC (method A)

Sources & evidence

ORD record
ord-8565759dac5e4722aa9abada09f0d263
Source dataset
uspto-grants-2010_05
Patent number
US07709494B2

Reaction notes

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