反应详情

温度

50 °C

A mixture of 4-(3,4-dichlorophenoxy)piperidine (WO 0058305, WO 0177101) (2.00 g), 2-(2-bromoethyl)oxirane (J. Am. Chem. Soc. 1981, 103, 7520-8) (1.36 g) and potassium carbonate (2.2 g) in acetone (20 ml) was stirred at 50° C. for 12 h. The solvent was removed under vacuum. The residue was partitioned between water and ethyl acetate. The organic layer was washed with water, brine and dried over magnesium sulfate. The mixture was filtered and the solvent was evaporated to afford the subtitle compound as a yellow oil (2.50 g) which was used without further purification in the next step.

1. customThe solvent was removed under vacuum
2. customThe residue was partitioned between water and ethyl acetate
3. washThe organic layer was washed with water, brine
4. dry with materialdried over magnesium sulfate
5. filtrationThe mixture was filtered
6. customthe solvent was evaporated