Hydrochloric Acid → HCID 59295961, compound

HRID 2233397Notes

Reaction equation

HRID 2233397 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([O:15]C)=[O:14].[OH-].[Na+].Cl>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([OH:15])=[O:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53429435Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

Product 1

HCID 59295961HCID 59295961, compoundYield 95.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate (1.3 g) in methanol (3 ml) was added a aqueous solution (3 ml) of sodium hydroxide (1 g) and the reaction mixture was heated at 80° C. for 3 h. The reaction was cooled to 20° C. and carefully acidified with concentrated hydrochloric acid. The white precipitate was isolated by filtration, washed with water and methanol to yield the title compound (1.16 g)

Workup

  1. temperatureThe reaction was cooled to 20° C.
  2. customThe white precipitate was isolated by filtration
  3. washwashed with water and methanol

Sources & evidence

ORD record
ord-0868ada0a3724d0eac7566f608a05aaf
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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