2-Hydroxy-1,3-benzothiazole-6-carboxylic acid → N-{4-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-3-hydroxybutyl}-2-oxo-2,3-dihydro-1,3-benzothiazole-6-carboxamide

HRID 2233410Notes

Reaction equation

HRID 2233410 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]([OH:21])[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH2:8][CH2:7]1.[O:22]=[C:23]1[NH:27][C:26]2[CH:28]=[CH:29][C:30]([C:32](O)=[O:33])=[CH:31][C:25]=2[S:24]1>>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[Cl:19])[O:12][CH:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH:4]([OH:21])[CH2:3][CH2:2][NH:1][C:32]([C:30]2[CH:29]=[CH:28][C:26]3[NH:27][C:23](=[O:22])[S:24][C:25]=3[CH:31]=2)=[O:33])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 141167092-Hydroxy-1,3-benzothiazole-6-carboxylic acidHCID 592960694-Amino-1-[4-(3,4-dichlorophenoxy)piperidin-1-yl]butan-2-ol

Product 1

HCID 59296029N-{4-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-3-hydroxybutyl}-2-oxo-2,3-dihydro-1,3-benzothiazole-6-carboxamide

Procedure

Prepared as described in Example 1 from 4-amino-1-[4-(3,4-dichlorophenoxy)piperidin-1-yl]butan-2-ol (0.26 g) and 2-oxo-2,3-dihydro-1,3-benzothiazole-6-carboxylic acid (0.152 g). Title compound obtained as a white solid (0.105 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2941c281dff94c80ba2e04bf303c1990
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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