Benzeneacetonitrile, 2-fluoro- → α-[(2-Fluorophenyl)methyl]-3-pyridinemethanamine

HRID 2233418Notes

Reaction equation

HRID 2233418 reaction equation
C(O[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][CH:6]=1)C.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][C:20]#[N:21]>>[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][C:4]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)=[O:11].[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][CH:20]([NH2:21])[C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 67592Benzeneacetonitrile, 2-fluoro-HCID 69188Ethyl Nicotinate

Product 2

HCID 22299528α-[(2-Fluorophenyl)methyl]-3-pyridinemethanamineHCID 60797714HCID 60797714, compound

Procedure

The title compound was generated from commercially available nicotinic acid ethyl ester and (2-fluoro-phenyl)-acetonitrile according to the general procedure D described above. The intermediates 2-(2-fluoro-phenyl)-1-pyridin-3-yl-ethanone and 2-(2-fluoro-phenyl)-1-pyridin-3-yl-ethylamine were isolated and characterized.

Sources & evidence

ORD record
ord-4e676fcbd6684caaaadff071dec477f8
Source dataset
uspto-grants-2010_05
Patent number
US07709507B2

Reaction notes

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