Methylhydrazine → HCID 357537, compound

HRID 223348Notes

Reaction equation

HRID 223348 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([C:12](=O)[CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:19][NH:20][NH2:21].[OH:22][CH2:23][CH2:24][NH:25][NH2:26]>>[CH3:19][N:20]1[C:15](=[O:17])[CH2:14][CH2:13][C:12]([C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:11][CH:10]=2)=[N:21]1.[OH:22][CH2:23][CH2:24][N:25]1[C:15](=[O:16])[CH2:14][CH2:13][C:12]([C:9]2[CH:10]=[CH:11][C:6]([N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:7][CH:8]=2)=[N:26]1

Participants

5

Reactant 3

HCID 6061MethylhydrazineHCID 80172-HydrazinoethanolHCID 13059431HCID 13059431, compound

Product 2

HCID 357537HCID 357537, compoundHCID 13233881HCID 13233881, compound

Procedure

Using the procedure of this Example, reaction of 4-(1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid with methyl hydrazine and 2-hydroxyethyl hydrazine gives 4,5-dihydro-2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone and 4,5-dihydro-2-(2-hydroxyethyl)-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone respectively.

Sources & evidence

ORD record
ord-c8adf25757e94ad3a46b40779dd60ef8
Source dataset
uspto-grants-1982_10
Patent number
US04353905

Reaction notes

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