反应详情

温度

0 °C

1.15 g crude [4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid were dissolved in 50 ml tetrahydrofuran and cooled in an ice bath to 0° C. At 0° C. 9.3 ml 1 M solution of borane tetrahydrofuran complex were added. The reaction mixture was warmed to 55° C. and stirred for one hour at this temperature. The reaction mixture was cooled in an ice bath and 50 ml water was added. The organic layer was added. The tetrahydrofuran was removed in vacuo and the residue extracted three times with portions of 80 ml ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4 and the solvent removed in vacuo to provide 1.1 g crude 2-[4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethanol as brown oil. This material was used without purification.

1. customAt 0° C
2. temperatureThe reaction mixture was warmed to 55° C.
3. temperatureThe reaction mixture was cooled in an ice bath
4. additionThe organic layer was added
5. customThe tetrahydrofuran was removed in vacuo
6. extractionthe residue extracted three times with portions of 80 ml ethyl acetate
7. washThe combined organic layers were washed with brine
8. dry with materialdried over MgSO4
9. customthe solvent removed in vacuo