反应详情

Together with 37.7 g of sodium iodide, 19.9 g of 4-chloromethyl-2-(4-methoxy-phenyl)-5-methyl-oxazole are, in 300 ml of acetone, heated at the boil under reflux for 2 hours. After cooling of the reaction mixture, the solvent was removed under reduced pressure and the residue dissolved in 300 ml of methyl tert-butyl ether, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4, and the solvent is then removed under reduced pressure. This gives 49.8 g of 4-Iodomethyl-2-(4-methoxyphenyl)-5-methyloxazole as a light-brown solid.

1. temperatureheated at the boil
2. temperatureunder reflux for 2 hours
3. temperatureAfter cooling of the reaction mixture
4. customthe solvent was removed under reduced pressure
5. dissolutionthe residue dissolved in 300 ml of methyl tert-butyl ether
6. washthe mixture is washed three times with saturated Na2S2O3 solution
7. dry with materialdried over MgSO4
8. customthe solvent is then removed under reduced pressure