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HRID223368

反应详情

EQUATION

反应方程式

HRID 223368 反应方程式

REACTANTS

反应物

2
Ammonium hydroxide 分子结构式
HCID14923

Ammonium hydroxide

H5NO

HCID 20522037 分子结构式
HCID20522037

未命名化合物

PRODUCTS

产物

1
9-(2-Phenylethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one 分子结构式
HCID13061731

9-(2-Phenylethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

C16H22N2O2

收率 97.1%

AUXILIARIES

试剂、催化剂与溶剂

1
Water 分子结构式
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 3.5 g of 9-(2-phenylethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride salt in water (50 ml) was adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride was evaporated to afford 3 g of 9-(2-phenylethyl)-1-oxa-4,9-diazaspiro-[5.5]undecan-3-one as the free base, m.p. 140°-141° C.

WORKUP

后处理

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride was evaporated