Chloroacetone → HCID 60624156, compound

HRID 2233738Notes

Reaction equation

HRID 2233738 reaction equation
Cl[CH2:2][C:3](=[O:5])[CH3:4].C(=O)([O-])[O-].[K+].[K+].[CH3:12][S:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1>CC(C)=O>[CH3:12][S:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:2][C:3](=[O:5])[CH3:4])=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 140864-(Methylthio)phenol

Product 1

HCID 60624156HCID 60624156, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of chloroacetone (10 ml), potassium carbonate (21 g), and 4-(methylthio)phenol (10 g) in acetone (200 ml) was heated under reflux for 6 h. The solvent was removed under reduced pressure and the residue partitioned between diethylether/water. The organics were separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5-10% ethylacetate/iso-hexane. Yield 12.43 g

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 h
  3. customThe solvent was removed under reduced pressure
  4. customthe residue partitioned between diethylether/water
  5. customThe organics were separated
  6. customdried
  7. customevaporated under reduced pressure
  8. customThe residue was purified by chromatography on silica eluting with 5-10% ethylacetate/iso-hexane

Sources & evidence

ORD record
ord-2dd79f18be04484da31c111ac062c955
Source dataset
uspto-grants-2010_05
Patent number
US07709521B2

Reaction notes

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