HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-Bromo-3-(4-chlorophenoxy)-2-methyl-4-nitro-1H-indole-1-acetic acid 1,1 dimethylethyl ester | HCID 68616945 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester | HCID 86609230 | — |
Reaction Steps
To a solution of the product from step (iii) (0.18 g) in EtOAc (30 ml) was added triethylamine (0.15 ml) and 5% Pt/C (36 mg) and the reaction stirred under hydrogen (1 atm) for 2 h. The reaction was filtered through celite and the filtrate evaporated under reduced pressure. Yield 0.139 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709521B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-ed29568ca60e40dab39b8b97d8cce620 |
| Source note | uspto-grants-2010_05 |