Potassium Hydroxide → HCID 13062078, compound

HRID 223376Notes

Reaction equation

HRID 223376 reaction equation
[CH2:1]([C:3]1([C:20]([O:22]CC)=[O:21])[CH:12]2[N:7]([CH2:8][CH2:9][C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][C:11]=32)[CH2:6][CH2:5][CH2:4]1)[CH3:2].[OH-].[K+]>C(O)C>[CH2:1]([C:3]1([C:20]([OH:22])=[O:21])[CH:12]2[N:7]([CH2:8][CH2:9][C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][C:11]=32)[CH2:6][CH2:5][CH2:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13062075HCID 13062075, compound

Product 1

HCID 13062078HCID 13062078, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into a solution of 6.8 g of 1-ethyl-1-ethoxycarbonyl-indolo(2,3-a)quinolizidine (12b-H; 1-C2H5 cis-isomer) obtained in the preceding example (d), in 100 ml of 95% ethanol, there are added 6.8 g of potassium hydroxide. The mixture is refluxed for 12 hours, the solvent evaporated under reduced pressure and the residue taken up in ice water and acidified with HCl to pH=4.5. The precipitated product is separated, washed and dried. 4.1 g of acid are thus obtained.

Workup

  1. temperatureThe mixture is refluxed for 12 hours
  2. customthe solvent evaporated under reduced pressure
  3. customThe precipitated product is separated
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-356ba9016ae04f4d9ae3b9a68f2a0986
Source dataset
uspto-grants-1982_10
Patent number
US04353911

Reaction notes

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