Potassium Hydroxide → HCID 13062078, compound

Participants

Reaction Steps

Into a solution of 6.8 g of 1-ethyl-1-ethoxycarbonyl-indolo(2,3-a)quinolizidine (12b-H; 1-C2H5 cis-isomer) obtained in the preceding example (d), in 100 ml of 95% ethanol, there are added 6.8 g of potassium hydroxide. The mixture is refluxed for 12 hours, the solvent evaporated under reduced pressure and the residue taken up in ice water and acidified with HCl to pH=4.5. The precipitated product is separated, washed and dried. 4.1 g of acid are thus obtained.

Provenance & Evidence