反应详情

A 4.27 ml portion of trifluoroacetic acid was added to 30 ml of dichloromethane solution containing 1.33 g of tert-butyl 2,4-difluoro-3-vinylbenzoate and stirred for 5 hours. After evaporation of the solvent, appropriate amounts of purified water and saturated sodium bicarbonate aqueous solution were added thereto and the water layer was washed with diethyl ether. The water layer was adjusted to pH 1 with 1 M hydrochloric acid aqueous solution, extracted with diethyl ether and then dried with anhydrous magnesium sulfate. After concentration, 964 mg (95%) of 2,4-difluoro-3-vinylbenzoic acid (Reference Example 6-1) was obtained.

1. customAfter evaporation of the solvent, appropriate amounts of purified water and saturated sodium bicarbonate aqueous solution
2. additionwere added
3. washthe water layer was washed with diethyl ether
4. extractionextracted with diethyl ether
5. dry with materialdried with anhydrous magnesium sulfate
6. concentrationAfter concentration