HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2,3-dihydro-7-methoxy-8-[2-(4-phenyl-1-piperazinyl)ethoxy]cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2,3-dihydro-8-[2-(methanesulfonyloxy)ethoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927716 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2,3-dihydro-7-methoxy-8-[2-(4-phenyl-1-piperazinyl)ethoxy]cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927687 | 90% |
Reaction Steps
Method B (24 h at 80° C.); starting materials: 2,3-dihydro-8-[2-(methanesulfonyloxy)ethoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 81) and 1-phenylpiperazine; yield 90%; fusion point 155°-156° C. (from isopropanol). Fumarate: method E; yield 94%; fusion point 182°-185° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-1a2f63fa05574a37bc8bd5d3321ac466 |
| Source note | uspto-grants-1995_06 |