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HRID22338

反应详情

EQUATION

反应方程式

HRID 22338 的结构方程式

REACTANTS

反应物

4
结构：CC(C)O
HCID3776

Isopropanol

C3H8O

结构：c1ccc(N2CCNCC2)cc1
HCID7096

Phenylpiperazine

C10H14N2

结构：O=C([O-])/C=C/C(=O)[O-]
HCID5460307

Fumerate

C4H2O4-2

结构：COc1cc2oc(=O)c3c(c2cc1OCCOS(C)(=O)=O)CCC3
HCID19927716

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2oc(=O)c3c(c2cc1OCCN1CCN(c2ccccc2)CC1)CCC3
HCID19927687

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Method B (24 h at 80° C.); starting materials: 2,3-dihydro-8-[2-(methanesulfonyloxy)ethoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 81) and 1-phenylpiperazine; yield 90%; fusion point 155°-156° C. (from isopropanol). Fumarate: method E; yield 94%; fusion point 182°-185° C. (from acetone).

WORKUP

后处理

  1. customMethod B (24 h at 80° C.)