反应详情

4-Amino-2,6-dichloropyrimidine (500 mg, 3.05 mmol) was refluxed in acetic anhydride (10 ml) for 3 h. Upon cooling to room temperature, the reaction mixture was cooled in an ice bath and basified to pH 8 with 10% aqueous NaHCO3. The phases were separated, and the aqueous portion was extracted twice with EtOAc. The combined organic portions were dried over Na2SO4, filtered, and concentrated to give an off-white solid (503.7 mg, 2.44 mmol, 80% yield).

1. temperaturethe reaction mixture was cooled in an ice bath
2. customThe phases were separated
3. extractionthe aqueous portion was extracted twice with EtOAc
4. dry with materialThe combined organic portions were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated