反应详情

3-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 31) (500 mg) was dissolved in anhydrous THF (5 ml) and cooled to 0° C. (Trimethylsilyl)diazomethane/ether (2 ml) was added. The mixture was stirred at room temperature under nitrogen gas for 1 h. The solvent was removed in vacuo and MeOH was added. The mixture was stirred for a further 15 min, the solvent was removed in vacuo and the solid was dried under vacuum to give the title compound (580 mg).

1. additionwas added
2. customThe solvent was removed in vacuo and MeOH
3. additionwas added
4. stirringThe mixture was stirred for a further 15 min
5. customthe solvent was removed in vacuo
6. customthe solid was dried under vacuum