Hydrochloric Acid → 1-(3-Nitropyridin-2-yl)piperidin-4-amine hydrochloride

HRID 2233836Notes

Reaction equation

HRID 2233836 reaction equation
[ClH:1].[N+:2]([C:5]1[C:6]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]>O1CCOCC1>[ClH:1].[N+:2]([C:5]1[C:6]([N:11]2[CH2:16][CH2:15][CH:14]([NH2:17])[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44120582HCID 44120582, compound2×

Product 1

HCID 457890031-(3-Nitropyridin-2-yl)piperidin-4-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4 N hydrochloric acid in dioxane (10 ml) was added to tert-butyl [1-(3-nitropyridin-2-yl)piperidin-4-yl]carbamate (Intermediate 38; 1.3 g, 4.2 mmol). The mixture was stirred at room temperature for 1 h under nitrogen gas. The solvent was removed in vacuo to give the title compound as a yellow powder (500 mg).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1094a111bd8d4978940bdef8e01aff93
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…