HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate | HCID 68580046 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride | HCID 68579843 | — |
Reaction Steps
4 N Hydrogen chloride in dioxane (3 ml) was added to tert-butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate (Intermediate 45, 0.29 mg 0.86 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo to afford the title compound (238 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-2c5bb347f265437e81bf009cf111d789 |
| Source note | uspto-grants-2010_05 |