Hydrochloric Acid → 6-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

HRID 2233841Notes

Reaction equation

HRID 2233841 reaction equation
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([S:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]2)[CH:4]=1>O1CCOCC1>[ClH:1].[NH2:17][CH:14]1[CH2:15][CH2:16][N:11]([C:5]2[N:6]=[C:7]([S:9][CH3:10])[N:8]=[C:3]([NH2:2])[CH:4]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68580046tert-Butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate2×

Product 1

HCID 685798436-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4 N Hydrogen chloride in dioxane (3 ml) was added to tert-butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate (Intermediate 45, 0.29 mg 0.86 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo to afford the title compound (238 mg).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2c5bb347f265437e81bf009cf111d789
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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