Hydroxyamine hydrochloride → HCID 136335750, compound

HRID 2233849Notes

Reaction equation

HRID 2233849 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]2)[CH:5]=[C:4]([C:22]#[N:23])[CH:3]=1.Cl.[NH2:25][OH:26]>CO>[NH2:23][C:22](=[N:25][OH:26])[C:4]1[CH:3]=[C:2]([Cl:1])[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:18])[CH3:19])[CH2:12][CH2:13]2)[CH:5]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86608248HCID 86608248, compound2×

Product 1

HCID 136335750HCID 136335750, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

TEA (0.24 ml, 1.78 mmol) was added to a solution of tert-butyl 1-(6-chloro-4-cyanopyridin-2-yl)piperidin-4-ylcarbamate (Intermediate 53, 0.4 g, 1.19 mmol) in MeOH (2 ml), followed by the addition of hydroxylamine hydrochloride (0.82 g, 1.19 mmol). The mixture was refluxed for 4 h, then the solvent was removed in vacuo to give the desired product. (410 mg).

Workup

  1. temperatureThe mixture was refluxed for 4 h
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-793cb0c70ba64ec9a7e0805227d6894b
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…