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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2233855Generated: October 31, 2026

Piperidin-4-ol → 2-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamide

https://huagongshe.com/reaction/2233855

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
Reactant2,6-DichloroisonicotinamideHCID 2781802—
Reactant2-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinonitrileHCID 83073403—
Product2-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamideHCID 86038381—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 26 starting from 2,6-dichloroisonicotinamide and 4-hydroxypiperidine (both commercially available).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709503B2
Source datasetuspto-grants-2010_05
ORD IDord-fa9add5fbc324f49a325cad3163a5ad5
Source noteuspto-grants-2010_05