Piperidin-4-ol → 2-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamide

HRID 2233855Notes

Reaction equation

HRID 2233855 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]2)[N:9]=1)[C:5]#[N:6].ClC1C=C(C=C(Cl)N=1)C(N)=[O:22].OC1CCNCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]2)[N:9]=1)[C:5]([NH2:6])=[O:22]

Participants

4

Reactant 3

HCID 79341Piperidin-4-olHCID 27818022,6-DichloroisonicotinamideHCID 830734032-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinonitrile

Product 1

HCID 860383812-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamide

Procedure

The title compound was prepared in a manner analogous to Intermediate 26 starting from 2,6-dichloroisonicotinamide and 4-hydroxypiperidine (both commercially available).

Sources & evidence

ORD record
ord-fa9add5fbc324f49a325cad3163a5ad5
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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