Methyl 2,4-dichloropyrimidine-6-carboxylate → methyl 2-chloro-6-methoxypyrimidine-4-carboxylate

HRID 2233875Notes

Reaction equation

HRID 2233875 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[C:7](Cl)[N:6]=1>CO>[Cl:4][C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:8]=[C:7]([O:2][CH3:1])[N:6]=1

Participants

4

Reactant 2

HCID 239689Methyl 2,4-dichloropyrimidine-6-carboxylateHCID 10942334Sodium Methoxide

Product 1

HCID 312614methyl 2-chloro-6-methoxypyrimidine-4-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A 0.5 M solution of sodium methoxide in MeOH was added slowly to a solution of methyl 2,6-dichloropyrimidine-4-carboxylate (0.30 g, 1.45 mmol) in MeOH (2 ml). A white precipitate formed which was stirred for further 15 minutes. The product was collected by filtration (0.20 g).

Workup

  1. customA white precipitate formed which
  2. filtrationThe product was collected by filtration (0.20 g)

Sources & evidence

ORD record
ord-db12317e5f6a4a6eba17a952909e5963
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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