HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2,4-dichloropyrimidine-6-carboxylate → methyl 2-chloro-6-methoxypyrimidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2,4-dichloropyrimidine-6-carboxylate | HCID 239689 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | methyl 2-chloro-6-methoxypyrimidine-4-carboxylate | HCID 312614 | — |
Reaction Steps
A 0.5 M solution of sodium methoxide in MeOH was added slowly to a solution of methyl 2,6-dichloropyrimidine-4-carboxylate (0.30 g, 1.45 mmol) in MeOH (2 ml). A white precipitate formed which was stirred for further 15 minutes. The product was collected by filtration (0.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-db12317e5f6a4a6eba17a952909e5963 |
| Source note | uspto-grants-2010_05 |