HCID 11514618, compound → N-[1-(Aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

HRID 2233881Notes

Reaction equation

HRID 2233881 reaction equation
[NH2:1][C:2]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11](=[O:17])OC(C)(C)C)[CH2:6][CH2:5]1)=[S:3].[Cl:18][C:19]1[C:23]([Cl:24])=[C:22](C)[NH:21][C:20]=1[C:26](NC1CCNCC1)=O>>[NH2:1][C:2]([N:4]1[CH2:5][CH2:6][CH:7]([NH:10][C:11]([C:22]2[NH:21][C:20]([CH3:26])=[C:19]([Cl:18])[C:23]=2[Cl:24])=[O:17])[CH2:8][CH2:9]1)=[S:3]

Participants

3

Reactant 2

HCID 11514618HCID 11514618, compound2×HCID 59296117tert-butyl N-(1-carbamothioylpiperidin-4-yl)carbamate

Product 1

HCID 86608262N-[1-(Aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

Procedure

The title compound was prepared by a procedure analogous to Intermediate 125 starting from 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide (Intermediate 90, 0.5 g, 2 mmol). The product was concentrated to a solid which was purified on a silica flash column (gradient elution from 0-5% MeOH in DCM over 30 min). Purification yielded a white solid (0.22 g).

Workup

  1. concentrationThe product was concentrated to a solid which
  2. customwas purified on a silica flash column (gradient elution from 0-5% MeOH in DCM over 30 min)
  3. customPurification

Sources & evidence

ORD record
ord-5074bc975ffa4e5fafa8b01ec6ef86bf
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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