HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 11514618, compound → N-[1-(Aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 11514618 | HCID 11514618 | — |
| Reactant | tert-butyl N-(1-carbamothioylpiperidin-4-yl)carbamate | HCID 59296117 | — |
| Product | N-[1-(Aminocarbonothioyl)piperidin-4-yl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide | HCID 86608262 | — |
Reaction Steps
The title compound was prepared by a procedure analogous to Intermediate 125 starting from 3,4-dichloro-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide (Intermediate 90, 0.5 g, 2 mmol). The product was concentrated to a solid which was purified on a silica flash column (gradient elution from 0-5% MeOH in DCM over 30 min). Purification yielded a white solid (0.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5074bc975ffa4e5fafa8b01ec6ef86bf |
| Source note | uspto-grants-2010_05 |