HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178441636, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Ethyl 4-cyano-5-methyl-1H-pyrrole-2-carboxylate | HCID 58066127 | — |
| Product | HCID 178441636 | HCID 178441636 | — |
Reaction Steps
Pentanimidamide hydrochloride (3.2 g) (prepared according to Garigipati, R. S.; Tetrahedron Lett 1990, 31 (14), 1969) was treated with ethyl acetoacetate (3.05 g) in a modified procedure using sodium (1.62 g) in anhydrous EtOH (50 ml) as base (as described in Salimbeni, Aldo; et al. J. Med. Chem. (1995), 38(24), 4806-20) affording the title compound (4.04 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-97e4c189db174a7db8893f763dd025bc |
| Source note | uspto-grants-2010_05 |