反应详情

Pentanimidamide hydrochloride (3.2 g) (prepared according to Garigipati, R. S.; Tetrahedron Lett 1990, 31 (14), 1969) was treated with ethyl acetoacetate (3.05 g) in a modified procedure using sodium (1.62 g) in anhydrous EtOH (50 ml) as base (as described in Salimbeni, Aldo; et al. J. Med. Chem. (1995), 38(24), 4806-20) affording the title compound (4.04 g).