Methyl4-chloroquinoline-2-carboxylate → HCID 46941938, compound

HRID 2233899Notes

Reaction equation

HRID 2233899 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2SC(C(OC)=O)=CN=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].ClC1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[N:28]=[C:27]([C:35]([O:37][CH3:38])=[O:36])[CH:26]=1>>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[N:28]=[C:27]([C:35]([O:37][CH3:38])=[O:36])[CH:26]=2)[CH2:13][CH2:14]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 19066063Methyl4-chloroquinoline-2-carboxylateHCID 59679281Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1,3-thiazole-5-carboxylate

Product 1

HCID 46941938HCID 46941938, compound

Procedure

The title compound was prepared by a procedure analogous to Intermediate 133 starting with methyl 4-chloroquinoline-2-carboxylate (WO 9505378). The product was purified on a silica gel flash column (0→5% MeOH in DCM) followed by recrystallization from EtOAc.

Workup

  1. customThe product was purified on a silica gel flash column (0→5% MeOH in DCM)
  2. customfollowed by recrystallization from EtOAc

Sources & evidence

ORD record
ord-1e42c11e93734919bb675e6375a4ae1f
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…