3,5-dimethyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(3,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

HRID 2233920Notes

Reaction equation

HRID 2233920 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[CH3:19][C:20]1[CH:24]=[C:23]([CH3:25])[NH:22][C:21]=1[C:26](O)=[O:27]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:26]([C:21]3[NH:22][C:23]([CH3:25])=[CH:24][C:20]=3[CH3:19])=[O:27])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]

Participants

3

Reactant 2

HCID 27764683,5-dimethyl-1H-pyrrole-2-carboxylic acidHCID 86608255HCID 86608255, compound2×

Product 1

HCID 866082732-Chloro-6-(4-{[(3,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

Procedure

Title compound was synthesized by an analogous method to Example 18 using 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) and 3,5-dimethyl-1H-pyrrole-2-carboxylic acid (commercially available).

Sources & evidence

ORD record
ord-5e4d7ca0f8db48bc9e85b4a17bb695a4
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

Loading…