3,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(3,4-dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

HRID 2233921Notes

Reaction equation

HRID 2233921 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[Cl:19][C:20]1[C:24]([Cl:25])=[C:23]([CH2:26][CH3:27])[NH:22][C:21]=1[C:28](O)=[O:29]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:28]([C:21]3[NH:22][C:23]([CH2:26][CH3:27])=[C:24]([Cl:25])[C:20]=3[Cl:19])=[O:29])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]

Participants

3

Reactant 2

HCID 685797083,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid2×HCID 866082552-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride2×

Product 1

HCID 251814252-Chloro-6-(4-{[(3,4-dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

Procedure

Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 3,4-dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 73).

Sources & evidence

ORD record
ord-5da01b023fc24e4fad819bb230c64d9f
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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