HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(3,4-dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid | HCID 68579708 | — |
| Reactant | 2-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride | HCID 86608255 | — |
| Product | 2-Chloro-6-(4-{[(3,4-dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide | HCID 25181425 | — |
Reaction Steps
Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 3,4-dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 73).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-5da01b023fc24e4fad819bb230c64d9f |
| Source note | uspto-grants-2010_05 |