3-ethyl-4,5-dimethyl-1H-pyrrole-2-carboxylic Acid → 2-Chloro-6-(4-{[(3-ethyl-4,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

HRID 2233922Notes

Reaction equation

HRID 2233922 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[CH2:19]([C:21]1[C:25]([CH3:26])=[C:24]([CH3:27])[NH:23][C:22]=1[C:28](O)=[O:29])[CH3:20]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:28]([C:22]3[NH:23][C:24]([CH3:27])=[C:25]([CH3:26])[C:21]=3[CH2:19][CH3:20])=[O:29])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]

Participants

3

Reactant 2

HCID 103296853-ethyl-4,5-dimethyl-1H-pyrrole-2-carboxylic AcidHCID 866082552-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride2×

Product 1

HCID 866082742-Chloro-6-(4-{[(3-ethyl-4,5-dimethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide

Procedure

Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 3-ethyl-4,5-dimethyl-1H-pyrrole-2-carboxylic acid (commercially available).

Sources & evidence

ORD record
ord-908005d20ada479abbba319168b680fa
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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