3,4-diethyl-5-methyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(3,4-diethyl-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide
Reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[CH2:19]([C:21]1[C:25]([CH2:26][CH3:27])=[C:24]([CH3:28])[NH:23][C:22]=1[C:29](O)=[O:30])[CH3:20]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:29]([C:22]3[NH:23][C:24]([CH3:28])=[C:25]([CH2:26][CH3:27])[C:21]=3[CH2:19][CH3:20])=[O:30])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]Participants
3
Procedure
Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 3,4-diethyl-5-methyl-1H-pyrrole-2-carboxylic acid (commercially available).
Sources & evidence
- ORD record
- ord-d15439374ab44551bd9ee179d2088691
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709503B2
Reaction notes
Loading…