3,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid → 2-(4-{[(3,4-Dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-5-carboxamide

HRID 2233927Notes

Reaction equation

HRID 2233927 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH2:8][CH3:9])[NH:4][C:3]=1[C:10]([OH:12])=O.Cl.[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]([C:26]([NH2:28])=[O:27])=[CH:24][N:25]=2)[CH2:17][CH2:16]1>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH2:8][CH3:9])[NH:4][C:3]=1[C:10]([NH:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]([C:26]([NH2:28])=[O:27])=[CH:24][N:25]=2)[CH2:17][CH2:16]1)=[O:12]

Participants

3

Reactant 2

HCID 685797083,4-Dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid2×HCID 68579945HCID 68579945, compound2×

Product 1

HCID 685825742-(4-{[(3,4-Dichloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-1,3-thiazole-5-carboxamide

Procedure

Title compound was synthesized by an analogous method to Example 29 by coupling 3,4-dichloro-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 73) with 2-(4-aminopiperidin-1-yl)-1,3-thiazole-5-carboxamide hydrochloride (Intermediate 81).

Sources & evidence

ORD record
ord-10881ef819ec41d98e32b9688e370ee6
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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