O-Methylhydroxylamine hydrochloride → HCID 86608280, compound

HRID 2233929Notes

Reaction equation

HRID 2233929 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([Cl:23])[N:20]=[C:19]([C:24]([OH:26])=O)[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7].Cl.[O:28]([NH2:30])[CH3:29]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([Cl:23])[N:20]=[C:19]([C:24]([NH:30][O:28][CH3:29])=[O:26])[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 86608278HCID 86608278, compound

Product 1

HCID 86608280HCID 86608280, compound

Procedure

Title compound was synthesized by an analogous method to Example 8 by coupling 6-(4-{[(4-bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-chloropyrimidine-4-carboxylic acid (Example 31) with methoxylamine hydrochloride (commercially available).

Sources & evidence

ORD record
ord-84192b2ac780456ba4f596997ee50188
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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