O-Methylhydroxylamine hydrochloride → HCID 86608281, compound

HRID 2233930Notes

Reaction equation

HRID 2233930 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([S:23][CH3:24])[N:20]=[C:19]([C:25](O)=[O:26])[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7].Cl.[O:29]([NH2:31])[CH3:30]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[N:22]=[C:21]([S:23][CH3:24])[N:20]=[C:19]([C:25]([NH:31][O:29][CH3:30])=[O:26])[CH:18]=3)[CH2:13][CH2:12]2)=[O:9])[NH:5][C:6]=1[CH3:7]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68579906HCID 68579906, compound

Product 1

HCID 86608281HCID 86608281, compound

Procedure

Title compound was synthesized by an analogous method to Example 8 by coupling 6-(4-{[(4-bromo-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-(methylthio)pyrimidine-4-carboxylic acid (Example 35) with methoxylamine hydrochloride (commercially available).

Sources & evidence

ORD record
ord-c2a53bbc035a4058becdf95d907c662e
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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