O-Methylhydroxylamine hydrochloride → HCID 86608284, compound

HRID 2233934Notes

Reaction equation

HRID 2233934 reaction equation
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([C:26](O)=[O:27])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10].Cl.[O:30]([NH2:32])[CH3:31]>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([C:26]([NH:32][O:30][CH3:31])=[O:27])[CH:19]=2)[CH2:14][CH2:13]1)=[O:10]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 68579985HCID 68579985, compound

Product 1

HCID 86608284HCID 86608284, compound

Procedure

The title compound was synthesised by an analogous method to Example 8 starting from 6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-2-methoxypyrimidine-4-carboxylic acid (Example 311) and methoxylamine hydrochloride.

Sources & evidence

ORD record
ord-d3fe1934ba7a4b0ebdf8a701f7d2815f
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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