HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178433661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 1-(6-Chloro-4-cyanopyridin-2-yl)piperidin-4-yl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate | HCID 86608294 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178433661 | HCID 178433661 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
1-(6-Chloro-4-cyanopyridin-2-yl)piperidin-4-yl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate (Example 308, 64 mg, 0.154 mmol), sodium azide (12 mg, 0.185 mmol) and ammonium chloride (8.3 mg, 0.154 mmol) were dissolved in anhydrous DMF (2 ml) and the mixture was heated at 120° C. for 8 h. The mixture was filtered and purified my semi-preparative reverse phase HPLC eluting with CH3CN/H2O (0.1% TFA) (48 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-08f34756443649acb495a099b66f7f02 |
| Source note | uspto-grants-2010_05 |