4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid → 4-Bromo-N-[1-(6-chloro-4-{[2-(methylamino)-2-oxoethyl]sulfanyl}-2-pyridinyl)-4-piperidinyl]-5-methyl-1H-pyrrole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid	HCID 68518222	—
Reactant	2-{[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]thio}-N-methylacetamide hydrochloride salt	HCID 86608304	—
Product	4-Bromo-N-[1-(6-chloro-4-{[2-(methylamino)-2-oxoethyl]sulfanyl}-2-pyridinyl)-4-piperidinyl]-5-methyl-1H-pyrrole-2-carboxamide	HCID 86608303	—

Reaction Steps

The title compound was prepared by analogous method to Example 18 starting from 2-{[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]thio}-N-methylacetamide hydrochloride salt (Intermediate 220) and 4-bromo-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 18).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07709503B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-266358524b424c7fb073eeaac57b5ed9
Source note	uspto-grants-2010_05