1-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt → N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

HRID 2233958Notes

Reaction equation

HRID 2233958 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([C:15](=[O:17])[CH3:16])[CH:12]=[C:11]([Cl:18])[N:10]=2)[CH2:5][CH2:4]1.[Cl:19][C:20]1[C:24]([Cl:25])=[C:23]([CH3:26])[NH:22][C:21]=1[C:27](NC1CCN(C2C=C(C3N=CON=3)C=C(Cl)N=2)CC1)=[O:28]>>[C:15]([C:13]1[CH:12]=[C:11]([Cl:18])[N:10]=[C:9]([N:6]2[CH2:7][CH2:8][CH:3]([NH:2][C:27]([C:21]3[NH:22][C:23]([CH3:26])=[C:24]([Cl:25])[C:20]=3[Cl:19])=[O:28])[CH2:4][CH2:5]2)[CH:14]=1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 866083141-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt2×HCID 866083163,4-Dichloro-N-{1-[6-chloro-4-(1,2,4-oxadiazol-3-yl)-2-pyridinyl]-4-piperidinyl}-5-methyl-1H-pyrrole-2-carboxamide2×

Product 1

HCID 86608290N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

Procedure

The title compound was synthesized by an analogous method to Example 18 starting from 1-[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt (Intermediate 197) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Sources & evidence

ORD record
ord-f0ebdaee25f1406aba300136788e4f9a
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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