1-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt → N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt	HCID 86608314	—
Reactant	3,4-Dichloro-N-{1-[6-chloro-4-(1,2,4-oxadiazol-3-yl)-2-pyridinyl]-4-piperidinyl}-5-methyl-1H-pyrrole-2-carboxamide	HCID 86608316	—
Product	N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-3,4-dichloro-5-methyl-1H-pyrrole-2-carboxamide	HCID 86608290	—

Reaction Steps

The title compound was synthesized by an analogous method to Example 18 starting from 1-[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt (Intermediate 197) and 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 3).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07709503B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-f0ebdaee25f1406aba300136788e4f9a
Source note	uspto-grants-2010_05