4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid → N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-4-bromo-5-methyl-1H-pyrrole-2-carboxamide
Reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([C:15](=[O:17])[CH3:16])[CH:12]=[C:11]([Cl:18])[N:10]=2)[CH2:5][CH2:4]1.[Br:19][C:20]1[CH:21]=[C:22]([C:26](O)=[O:27])[NH:23][C:24]=1[CH3:25]>>[C:15]([C:13]1[CH:12]=[C:11]([Cl:18])[N:10]=[C:9]([N:6]2[CH2:7][CH2:8][CH:3]([NH:2][C:26]([C:22]3[NH:23][C:24]([CH3:25])=[C:20]([Br:19])[CH:21]=3)=[O:27])[CH2:4][CH2:5]2)[CH:14]=1)(=[O:17])[CH3:16]Participants
3
Procedure
The title compound was synthesized by an analogous method to Example 42 starting from 1-1-[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt (Intermediate 197) and 4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 18).
Sources & evidence
- ORD record
- ord-3ce457e4f6f74459846a3579f6b24ac2
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709503B2
Reaction notes
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