HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid → N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-4-bromo-5-methyl-1H-pyrrole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid | HCID 68518222 | — |
| Reactant | 1-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt | HCID 86608314 | — |
| Product | N-[1-(4-Acetyl-6-chloro-2-pyridinyl)-4-piperidinyl]-4-bromo-5-methyl-1H-pyrrole-2-carboxamide | HCID 86608317 | — |
Reaction Steps
The title compound was synthesized by an analogous method to Example 42 starting from 1-1-[2-(4-aminopiperidin-1-yl)-6-chloropyridin-4-yl]ethanone hydrochloride salt (Intermediate 197) and 4-Bromo-5-methyl-1H-pyrrole-2-carboxylic acid (Intermediate 18).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709503B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-3ce457e4f6f74459846a3579f6b24ac2 |
| Source note | uspto-grants-2010_05 |