1-Methyl-2-imidazolecarboxaldehyde → 4-Bromo-5-methyl-N-{1-[(1-methyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-1H-pyrrole-2-carboxamide

HRID 2233963Notes

Reaction equation

HRID 2233963 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:10])[NH:6][C:7]=1[CH3:8].[CH3:18][N:19]1[CH:23]=[CH:22][N:21]=[C:20]1[CH:24]=O>>[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:24][C:20]3[N:19]([CH3:18])[CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:17]2)=[O:10])[NH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 1395751-Methyl-2-imidazolecarboxaldehydeHCID 68579819HCID 68579819, compound2×

Product 1

HCID 685800144-Bromo-5-methyl-N-{1-[(1-methyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-1H-pyrrole-2-carboxamide

Procedure

Title compound was synthesized by an analogous method to Example 1 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 1-methyl-1H-imidazole-2-carbaldehyde (commercially available).

Sources & evidence

ORD record
ord-c892e9141c0d4caab548f81fbffee484
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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