2-Bromo-1,3-benzothiazole → N-[1-(1,3-benzothiazol-2-yl)piperidin-4-yl]-4-bromo-5-methyl-1H-pyrrole-2-carboxamide

HRID 2233966Notes

Reaction equation

HRID 2233966 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:10])[NH:6][C:7]=1[CH3:8].Br[C:19]1[S:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=1>>[S:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=[C:19]1[N:15]1[CH2:14][CH2:13][CH:12]([NH:11][C:9]([C:5]2[NH:6][C:7]([CH3:8])=[C:3]([Br:2])[CH:4]=2)=[O:10])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 6120402-Bromo-1,3-benzothiazoleHCID 68579819HCID 68579819, compound2×

Product 1

HCID 68582949N-[1-(1,3-benzothiazol-2-yl)piperidin-4-yl]-4-bromo-5-methyl-1H-pyrrole-2-carboxamide

Procedure

Title compound was synthesized by an analogous method to Example 123 by coupling 4-bromo-5-methyl-N-piperidin-4-yl-1H-pyrrole-2-carboxamide hydrochloride (Intermediate 57) with 2-bromo-1,3-benzothiazole (commercially available).

Sources & evidence

ORD record
ord-43bab24f15dd4a498704f29a7c10edaa
Source dataset
uspto-grants-2010_05
Patent number
US07709503B2

Reaction notes

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